Course Goals: This is a course in three parts, each part designed to allow you to acquire specific knowledge and skills in Developmental Biology. In the lecture component, our present understanding of developmental processes (biological literacy) will be examined and your success with this knowledge will be assessed in written examinations. In the "standard" laboratory component, you will have the opportunity to observe and manipulate developing organisms, thus acquiring first hand knowledge of development and skills in handling and observation. To allow me to assess your progress in handling and observing developing organisms you will keep a detailed laboratory notebook. In the third component of the course, you will apply your skills in biological inquiry and communication as you research, design, conduct and report an independent investigation on genes in development. Your learning in this project will be assessed in a group presentation and in individual research papers.
Dr.
Frances E. Weaver
Office: Kirkbride 423A, ext. 4519
Office hours: MWF 10-10:50, T
Email: feweaver@mail.widener.edu
Text: S.F.
Gilbert, Developmental Biology , 8th edition, Sinauer
Associates,
Lab Atlas:
G.C. Schoenwolf, W.W. Mathews Atlas of
Descriptive Embryology, 6th edition
Prentice Hall, Upper Saddle River, NJ 2003
(You may share the cost of the atlas)
Other
supplies:
A separate notebook for laboratory, available from the instructor at no cost to
you
A laboratory manual prepared for this course will
also be distributed at no cost, you need only purchase
a 1” three ring binder for this manual.
Lab
coats are required, dissecting kits are
recommended.
Course Requirements:
Lecture Portion: |
|
Two exams @ 125 each |
250 |
One compulsory "final" exam |
250 |
Standard laboratory component: |
|
Review of laboratory notebook* |
60 (collected twice @30 ) |
Research based laboratory
component (as a group unless specified):
|
20 |
Draft of literature review |
40 |
Draft of methodology |
30 |
Genes and development mini project power point presentation. |
50 points based on instructor
evaluation. |
Peer evaluation of mini project reports (written by each individual) |
20 |
Final written report of research project |
100 |
Your final grade will be based on the percentage of the 830 possible points that you earn. +/- grading will be used in this course.
* Laboratory "ends" when the exercise is completed, that might be in three days time. Embryos will develop (or not) at their own pace! Please be informed that considerable out of class effort is required in this course. Failure to complete out of class observations or experimentation or to completely record these in your laboratory notebook will considerably reduce your grade!
Campus Cruiser and course web page: We will use the Campus Cruiser site for the course for announcements, email and for other materials. This web site may also be used to link to on-line resources.
Attendance is required. There are no make-ups for missed lectures or labs. You will receive a grade of zero for any lab that you miss. It is not possible to obtain materials for an additional lab period. Some “lecture” hours are spent in lab, this is especially true of Friday mornings. Please be aware of this and plan accordingly.
Exams: Exams may be made-up only under
extreme, documented circumstances and at my convenience!
It will not be possible to take an exam prior to the day it is scheduled. Everyone must take the final.
Written Assignments and Presentations:
We will adhere strictly to the dates
listed on the syllabus.
Extensions are rarely given in this course, so get your work done and turn
it in on time!
Useful information: I am here every day and you are welcome in my office or laboratory at any time. Voice mail and e-mail operate 24 hrs. a day and I can access both from off-campus. Notes may be left for me on my office door. If you are unable to reach me by any of these means; you may leave a message with the Science Office, KH325, ext. 4003.
Alternative testing: I provide alternative testing to students with documented
special needs. Just ask.
Alternative note taking: You may tape record lectures for your personal
use.
Academic Integrity:
The Science Division strongly enforces
If you
do violate the University policy, I will not hesitate to fail you in this
course, regardless of your academic standing!
*Laboratory Notebooks: Each student will keep a detailed, dated laboratory notebook of all activities in the lab, which will include, but are not limited to, all methodologies, observations (many of which will take place outside of the scheduled lab period) including drawings, raw and analyzed data, discussions and suggestions for future experiments or improvements to the lab. Lab notebooks will be collected and graded as indicated, and returned to each student the following week (or sooner as necessary). I expect your lab notebook to improve each time it is turned in. A GOOD LAB NOTEBOOK IS PRECISE, DETAILED AND LEGIBLE!!!!!
I reserve the right to modify the syllabus, this may include, but is not limited to, changes in the order of laboratories to accommodate shipping and preparation schedules. Changes will be announced in class, or on Campus Cruiser or by email.
LECTURE SEQUENCE Please note: topics rarely fit neatly into 50 minute blocks. Material will "spill over" as is necessary.
Date |
Topic |
Chapter |
Jan. 14, 16, 20 |
Intro-the anatomical tradition: Principles
of Developmental Anatomy |
1 2 |
23, 25 |
Life Cycles and Developmental
Patterns The Genetic core of Development: review of some molecular techniques |
2 3 4 pp. 81-98 |
28, 30, 1 |
The Genetic core of Development: The Germ Line, Eggs and Sperm |
19, 7 |
4, 6, 8 |
Fertilization |
7, 8 |
11, 13, 15 |
Early Developmental Processes:
Illustrated by Invertebrates |
8, 9 |
18, 20, 22 |
Drosophila cont. |
9 |
Feb 25th |
Exam I , covers chapters 1, 2, 4, 19 and 7. This will be an in
class exam |
|
27, 29 |
Early Development of Vertebrates |
10, 11 |
March 3-7 |
Spring Break |
|
10, 12, 14 |
Early Development of Vertebrates |
11 |
17, 19 |
CNS and Sensory Organs; Neural
Crest (Spring |
12, 13 |
24, 26, 28 |
Neural Crest |
13 |
31 Apr 2, 4 |
Mesoderm and Endoderm |
14, 15 |
7, 9 |
Mesoderm and Endoderm |
14, 15 |
April 14, due 18th |
Exam II |
|
14, 16 |
Limb Development, (Student Project's day April 18) |
16 |
21, 23, 25 |
Sex Determination |
17 |
28, 30, May 2 |
Sex Determination, Selected
Topics TAKE HOME FINAL EXAM DURING FINALS WEEK (May 2-7) |
17 |
Date |
Exercise |
1/17/08 |
Lecture Form groups and begin background research for genes and development
project |
1/24/08 |
Differentiation in Dictyostelium
discoideum. Regeneration in Lumbriculus* |
1/31/08 |
Gametes and Gametogenesis,
Meiosis and Plan Genes and Development experiments, work on ordering this week |
2/07/08 |
Xenopus, zebra fish* and sea urchin* (if available) fertilization and early development. Data collection for Lumbriculus* |
2/14/08 |
Continue observations of Xenopus, zebra fish* and sea urchin* if possible |
2/21/08 |
Genes and
Development project |
2/28/08 |
Genes and
Development project |
3/08/08 |
Spring Break |
3/13/08 |
Genes and
Development project |
3/20/08 |
Genes and
Development project |
3/27/08 |
Chick development I:
Observations Draft of methods due |
4/03/08 |
Chick development II: Blastoderm explanation and cardia bifida* (repeat if needed) ; Staining embryos for cartilage* |
4/10/08 |
No lab –
Weaver will complete staining for you |
4/17/08 |
Observe cartilage staining , Presentations
in lecture on the 21st. |
4/24/08 |
Mammalian development, Peer reviews of presentations due |
5/01/08 |
Lab notebooks collected Final written reports of the Genes and Development
project are due NO LATER THAN THE END OF FINALS WEEK |
* observations continue beyond this period.
Bio 306 2008
REVISED Calendar for Graded Work (strike through items are complete)
2/22/08 Exam I
2/28/08 Lab note books collected
3/14/08 Literature review outline due (email or upload
to Campus Cruiser)
3/21/08 Draft of literature review due (email or
upload to Campus cruiser) (one of you isn’t
done here)
3/27/08 Draft of methodology section due (an additional
draft of lit. review is recommended) PAST DUE
4/18/08 Exam II is
due
4/21/08 Presentations (person on the bubble may be
presenting on 4/23)
4/24/08 Peer reviews of presentations due
5/01/08 Lab notebooks collected
Finals week Final Exam (take home, which I hope to have ready early)
End of Finals week Final written reports due