Biology 261
REVISED Principles of Cellular and Molecular
Biology: Fall 2008 REVISED
Warm ups on Campus Cruiser |
Dr. Frances E. Weaver
Office Kirkbride
423A Phone: 610 499-4519
Office hours: M 11:00-11:50; T
2:00-2:50; W-F 1:00-1:50 or by appointment
Email: feweaver@mail.widener.edu
Class Times: MWF 10:00-10:50 and F 12:00-12:50 KH 229
Laboratory Times: T 11:00-1:50 (A) or Th 8:00-10:50 (B) KH 403 or M 1:00-3:50 (C); KH 403
Required texts:
The World of the Cell 7th edition by Becker, Kleinsmith and Hardin
Benjamin Cummings Publishing Company; San Francisco CA; 2009 (This is a new edition)
Laboratory Manual for Biology 261, F. Weaver, ed., 2008. To be purchased prior to the first lab.
Course Goals: A. To develop
literacy in cell biology. Literacy in cell biology
will be assessed on lecture examinations and in quizzes. B. To reinforce scientific process skills. Increased scientific process skills will be assessed in
laboratory activities. C. To
reinforce skills in oral and written communication. Skills in written and oral communication will
be assessed in two group oral presentations, two laboratory reports and a
reflective paper. D. To cultivate the understanding that the
study of cellular and molecular biology is connected to social issues. Recognition of these connections will be
assessed in a group case study presentation and in an individual reflective
paper. E. To prepare students for entry
into Biology 262, Principles of Modern Genetics. Satisfactory completion of
this course is required for admission to Biology 262. For course objectives,
follow the link above.
Regarding Office Hours: You are invited to drop in to my office at any time. You
are welcome in my laboratory at any time.
I also have standing office hours, the times for which are shown. You
are encouraged to bring any and all questions directly to me in person or by phone
or email. If your schedule does not match mine, I will make time for you!
Email and Course Web Page: Each student is to be familiar with the course web page and Campus Cruiser site. Many assignments must be submitted electronically, notably the Warm-ups. Announcements, shared files and other information will appear on the Campus Cruiser site, using either direct postings or links to the syllabus. With the exception of the syllabus, web page material will not be distributed on paper unless I deem it necessary. You may use email for all types of questions pertaining to the course, if necessary, please forward your Campus Cruiser email to the account you check daily.
Course Requirements
Lecture
Laboratory
GRAND TOTAL = 1000
points
Academic Integrity: The course instructor and the
Science Division strictly enforce the University's policy on Academic Integrity
as outlined in the Student Handbook.
The University Policy is that anyone who cheats, attempts to cheat or assists another
student to cheat on an exam or quiz fails the course. Other common violations such as submitting
collaborative work when not authorized to do so, and plagiarism also
result in failure. All of these violations mean that you
expect to be given credit for work that is not your own, and that is clearly
academic fraud. If you would like further clarification, read
Standards for Academic Integrity in the student handbook. If you are
uncertain how to proceed in any situation, contact me before you make a costly
mistake! If you do violate the University policy, I will not hesitate to fail you in this course,
regardless of your academic standing!
Attendance:
Consistent, attentive attendance is the key to success in this course.
Activities that take place in class cannot be made up!!!
Grading:
Your grade is based on the percentage of the 1000 possible points that you
earn. Thus 950/1000 = 95%; 750/100 = 75% etc. The +/- system will be used in
this course.
Please be advised that I use this scheme to
assign grades and all adjustments such as +/- are made at my discretion!!
A 95%
or above
A- 90-94%
B- to B+ 80-89%
C- to C+ 70-79%
D to D+ 60-69%
Review sessions: Group review
sessions will usually be held on one or two evenings of the week before an
exam. Attendance at review sessions is optional but is strongly
encouraged.
Exams: Missed exams result in a grade of ZERO!
Times: Exams take place during the Friday noon section as listed on the
attached schedule, the format varies with each exam.
The final exam is cumulative and will review the semester's work.
Make ups :
Make up exams are given only under conditions of documented emergencies.
NO OTHER MAKE UPS WILL BE GIVEN ! I
reserve the right to schedule make up exams and will do so only after I
have received appropriate documentation.
Make-up exams will differ in content and format from scheduled exams.
Early exams:
A student may request to take an exam early for personal, athletic or academic
reasons. Requests for early exams must be received IN WRITING (email is acceptable) no later
than ONE WEEK BEFORE the scheduled date of the exam. Early exams will differ in
content and format from regularly scheduled exams. Exams for those rare
individuals with course conflicts are given at MY convenience.
Late exams or late for exams: No late exams will be
given. See make-up policy above. Students late to exams will have the time
remaining in the period to finish, period, that's it, no excuses!
Warm-ups: Warm-ups are distributed electronically and are completed
as assignments in Campus Cruiser. Each warm up is due by 6:30
a.m. Monday as each week of class begins. Submission closes at that time.
Warm ups must be done without assistance from anyone else in the class or
the purpose of the warm-up is defeated. Warm-ups will be used to determine
the depth and pace at which we explore cell biology together. It is essential that you complete every warm
up, but to anticipate the unexpected, I will drop the two lowest grades. Failure
to cite your sources will result in a grade of ZERO for any warm up!
Quizzes: Post quizzes take place in the Friday noon section. These
quizzes are worth 15 points. Expect to
devote at least 30 minutes to taking each quiz. You may take a quiz only at
the time it is scheduled. Missed
quizzes result in a grade of ZERO! Quizzes may not be taken early.
Again, anticipating the unexpected, I will drop the score of one and only
one quiz. Exceptions to these rules are made only for those rare individuals with course conflicts or
those celebrating religious holidays. Alternate quizzes given for
these reasons are scheduled at MY convenience.
Cases Presentation and Case Paper: These are real world situations designed to permit
you to direct your own learning about various aspects of cellular and molecular
biology that we will work with in laboratory time. More information on cases
may be found in the laboratory manual.
Science Division Seminars: Biology 261 students are expected to attend the
Science Division Seminars sponsored by the Biology Department. An extra credit
question on each seminar topic will appear on the exam following each seminar.
A copy of the Science Division Seminar schedule is be available on-line.
Useful information: I am here every
weekday. Voice mail, e-mail and the course web sites operate 24 hrs a day. The bulletin board next to my office door has
yet to fall off, but if you are unable to reach me by these means; you
may leave a message with the Science Office, KH323, ext. 4003.
Alternative testing: I can provide alternative testing or extra time for testing
to students with documented special needs.
Just ask.
Alternative note taking: You may record lectures and review sessions for your
personal use.
Other
alternatives are available for students
with documented special needs. Just ask.
Special assistance: The following people and organizations are here to help
YOU!
DO NOT WAIT UNTIL YOU ARE OVER YOUR HEAD TO ASK
FOR HELP!
The first thing to do is talk to me. I can arrange
special assistance, discuss study or note taking skills, introduce you to the
reading and academic skills center, answer any and all questions about the
course material or requirements, solve problems arising from labs, be your
liaison with other faculty, help you find other students with which to form a
study group etc.
For additional help including regular, no cost,
tutoring I will refer you to the
Your academic advisor will assist you in
coordinating your program of study and provide a valuable reference in all
areas of academic life. Advisors in the
Biology department do check with me about student progress.
It is our
expectation that we will treat one another with courtesy, that we will have
fun, and that you will all succeed.
Lecture Schedule
Dates |
Topics |
Activities |
The World of the Cell |
Sept. 5 |
Cellular chemistry, Macromolecules |
set up/modify email |
1, 2 |
Sept. 8, 10, 12 |
Cellular chemistry, Macromolecules |
Warm-up (due 9/8) Quiz |
2, 3, 4 |
Sept. 15, 17, 19 |
Cells and Organelles |
Warm-up (due 9/15) Quiz |
4 |
Sept. 22, 24, 26 |
Bioenergetics and Enzymes |
Warm-up (due 9/22) Quiz |
5, 6 |
Sept. 29, Oct. 1, 3 |
Membranes and Transport |
Warm-up (due 9/29) |
7 (all but 158-162) 8 |
Oct. 6, 8, 10 |
Transport, Signaling, Junctions |
|
8 14 pp 392 to 406 17 484-490 |
Oct. 10 NOON Exam I |
EXAM I (up to Oct 3 or as announced) (Note: First lab report due in lab this week) |
Review and practice |
|
Oct. 13, 15 |
Metabolism part I: Glycolysis, Fermentation, |
Warm-up (due 10/13) |
9 |
Oct. 22, 24 |
Metabolism part II |
Quiz |
9, 10 |
Oct. 27, 29, Nov. 1 |
Metabolism part III: Photosynthesis |
Warm-up (due 10/27) Quiz |
11 to page 315 |
Nov. 3, 5, 7 |
Complete photosynthesis DNA |
Warm-up (due 11/3) |
11 as above 18 |
Nov 7 NOON Exam II |
EXAM II (up to Nov 1 or as announced) |
Review and practice |
|
Nov. 10, 12, 14 |
DNA replication, Cell Cycle and Mitosis (quick review only) |
Warm-up (due 11/10) Quiz |
19 20 skip 620-28 20 628-end read for appropriate labs |
Nov. 17, 19, 21 |
Meiosis, Gene Expression I |
Warm-up (due 11/17) Quiz |
20 as above 21 |
Nov. 24, 26 |
Gene Expression continued (Thanksgiving Nov. 27-28 ) |
|
21 22 to page 697 overview of sorting |
Dec. 2, 3, 5 |
Gene Expression and Regulation of Eukaryotic Gene Expression |
Warm-up (due 12/01) Quiz |
22 as above 23 start at page 723 |
Dec. 5 NOON Exam III |
EXAM III Up to Dec 2 or as announced (Note: Case study presentations this week in lab) |
Review and practice |
|
Dec. 8, 10, 12 |
Regulation of Gene Expression |
Warm up (due 12/08) Quiz |
23 |
Final Exam as scheduled by
the registrar during Dec 14-18th
|
FINAL Up to Dec 12, cumulative The final exam is cumulative and will also include any new material we touch on after Dec 5th. |
Review and practice |
|
I reserve the right to modify the syllabus. Modifications will be announced in class or
on Campus Cruiser, or distributed by email.
Biology 261
Laboratory Fall 2008
This is a component of Biology 261 and carries no credit as
a separate course.
Instructor: Dr.
Frances E. Weaver, Kirkbride 423A, ext. 4519
Office
Hours: As on lecture syllabus
Email: feweaver@mail.widener.edu
Required text: F. Weaver, ed. Laboratory
Manual for Biology 261, 2008 to be purchased from the instructor prior
to the first lab. Laboratory coats are also required
You are expected to have read and understood the lab
exercise before coming to the laboratory!
You are expected to be on time for lab we are going to be
very very busy!
Safety:
You must follow all safety guidelines for each laboratory
NO FOOD OR DRINK EVER IN THIS LABORATORY
You are expected to purchase a lab coat and wear it in the laboratory each and every
lab!
You must wear
closed toe shoes.
Safety glasses and gloves will be
provided as necessary.
The instructor will demonstrate
the location and location and proper use of all safety equipment.
Follow the safe handling and
disposal guidelines for all chemicals and biologicals.
Report spills or injuries to the
instructor.
Laboratory requirements (included as part of the Biology
261 total)
Grading A schedule of
assignments and point values is given on the next page. Additional information
precedes each week's laboratory.
ATTENDANCE IS REQUIRED.
You must
attend lab in your assigned section, but if a problem arises consult ME BEFORE you miss a lab!
There are ABSOLUTELY no make-ups for any missed lab!!!
Late work: Laboratory reports lose 10% of their value for each day late. Example:
a lab report worth 30 points is turned in two days late. 30 X 0.1 = 3
3 X 2 days late = 6.
30-6 = 24 maximum possible score.
Other laboratory assignments will receive a zero after the due date.
Extensions are given only under extreme circumstances.
Academic integrity: The Widener University Science Division strictly enforces
the University's policies on Academic Integrity.
I reserve the right to modify the syllabus Modifications
will be announced in lab or in class, or posted on Campus Cruiser or
distributed by email.
Biology 261 - Fall 2008
Laboratory Schedule and Requirements
Dates |
Title |
Due from this lab
(pts) |
9/4 |
No labs, Please
purchase your lab manual |
|
9/8, 9/9, 9/11 |
Introduction to cells and organelles and review of microscope use. |
Sketches (10) Calculation Questions (10) |
9/15, 9/16, 9/18 |
Macromolecules: DNA isolation and quantification Gel electrophoresis of muscle proteins |
Data sheets (20) |
9/22, 9/23, 9/25 |
Prokaryote unknowns: morphology, culture and metabolic characteristics |
Gram stain and preliminary data (10) |
9/29, 9/30, 10/2 |
Diffusion and Osmosis Prokaryote unknowns: data collection and identification. |
Hypothesis and method for diffusion and osmosis. (15) Identification of unknown. (10) |
10/6, 10/7, 10/9 |
Enzymes I: Basic experiments with tyrosinase (Note: lecture exam
10/10) |
Report on diffusion and osmosis (30)* Protocol (written at start of lab) (10) In lab data analysis (20) |
10/13, 10/14, 10/16 |
Enzymes II: Student designed tyrosinase study
|
Hypothesis and protocol (20), due two days before lab In lab data analysis (20) |
10/20 Fall Break
10/21 and 10/23 only |
Oral presentations of the tyrosinase study Assignment of cases MONDAY LAB STUDENTS MUST ATTEND ANOTHER SECTION THIS WEEK OR PRESENT ON FRIDAY AT NOON |
Oral presentation (10)
|
10/27, 10/28, 10/30 |
Monday lab meet to assign and discuss case studies only All other times- work on case studies Enzyme Reports ARE due |
Written report on enzymes II
(30)* |
11/3, 11/4, 11/6 |
Molecular
Biology, part I: Bacterial transformation
and streak plates for project Photosynthesis
(may be moved around if we are
behind in lecture) (Note: lecture exam 11/7) |
Photosynthesis Questions for Consideration (20) (may
be moved around if we are behind in lecture) |
11/10, 11/11, 11/13 |
Molecular
Biology, part II: Plasmid isolation and
restriction enzyme digestion Conferences with instructor on case
studies |
Molecular
Biology I data sheet (15) |
11/17, 11/18, 11/20 |
Molecular Biology, part III: Bioinformatics PREPARE CASE STUDY PRESENTATIONS |
Molecular Biology
II data sheet
(20) Bioinformatics data sheets (10) |
11/24, 11/25, 11/27 |
NO LABS –THANKSGIVING BREAK |
|
12/1, 12/2, 12/4 |
CASE STUDY PRESENTATIONS (Note: lecture exam 12/5) |
Group presentation of cases (30) |
12/8, 12/9, 12/11 |
Clean up week, no labs scheduled. Finish all rewrites and papers and turn everything in ! |
Individual reflective papers on cases (30) |
* loses 10% of the maximum value for each day late. Rewrites are possible for both lab reports, consult
your lab manual.
RESOURCES
Resource links are updated
frequently, check back often
Answers to Warm Ups |
Quiz and Exam Answers |
Old Exams etc. |
Internet Resources |
More Internet Resources |
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Old Exam 3 Questions (see your shared files) |
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Glycolysis complex animation, very cool** • http://www.johnkyrk.com/glycolysis.html TCA animation, similarly § http://www.johnkyrk.com/krebs.html Glycolysis chemical structres (static) • http://www.gwu.edu/~mpb/glycolysis.htm Other |
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Wu-6 was
cancelled |
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Non interactive, simplified animation of photophosphorylation |
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Animations on DNA replication, Hershey-Chase, Meselson and Stahl |
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**John Kyrk has an MS in biology from Harvard. His web site www.johnkyrk.com has many other cell bio animations. |
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