| Andrea E. Martin, Ph.D. | |
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Research Interest
Reactions at Binuclear Transition Metal Centers The role of metalloproteins in
binding and activating small molecules in biological systems forms the
inspiration for this work. I am specifically interested in modeling enzymes
with active sites which contain two transition metal ions. Two metals in
close proximity bind and activate substrates in ways that cannot be observed
with a single metal ion. In my work, macrocyclic ligands like that shown
below are used to form binuclear metal complexes. Using common organic
synthesis techniques, we can prepare a variety of ligands, which are reacted
with different transition metals. The resulting coordination complexes are
characterized and used for binding and reactivity studies. |
